The Effect of Cerebrospinal Fluid Pressure on Perilymphatic Flow in the Opened Cochlea

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Abstract
Scala tympani of guinea pigs was perfused with elevated potassium solutions whose concentrations were measured with ion-sensitive pipettes. It was noted that, upon spontaneous recovery, the concentration curve showed a 'break' approximately 3 min after perfusion ceased. When the CSF pressure was released by opening the cisterna magna, cochlear flow was markedly reduced, and the recovery curve became smoothly exponential, following a much slower return to control levels. This finding lends support to the idea proposed by Moscovitch, Gannon &Laszlo (1973) that longitudinal flow of CSF contributes to perilymph efflux in the patent cochlea.

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