Influence of Interleukin‐10 onAspergillus fumigatusInfection in Patients with Cystic Fibrosis
Open Access
- 1 June 2005
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 191 (11) , 1988-1991
- https://doi.org/10.1086/429964
Abstract
Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)–10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position −1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the −1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CFKeywords
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