New Antimicrobial Nitrofuran, trans -5-Amino-3-[2-(5-Nitro-2-Furyl)Vinyl]-Δ 2 -1,2,4-Oxadiazole: Antibacterial, Antifungal, and Antiprotozoal Activities In Vitro
- 1 September 1974
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 6 (3) , 263-267
- https://doi.org/10.1128/aac.6.3.263
Abstract
trans -5-amino-3-[2-(5-nitro-2-furyl)vinyl]-Δ 2 -1,2,4-oxadiazole, a new antimicrobial nitrofuran, has shown microbial activity in vitro against a wide range of bacteria and fungi, and against several protozoa. The antimicrobial activity of the nitrofuran is not significantly diminished in vitro in the presence of 50% human serum. The compound is not cross-resistant with a number of common antibiotics or synthetic antimicrobial agents; some cross-resistance with furazolidone is encountered. The development of resistance to the compound in vitro, when it occurs, is mixed, but is unrelated to increase in pathogenicity of the test organism.Keywords
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