INFLUENCE OF AGE ON THYROIDAL I-131 UPTAKE IN BEAGLE PUPS

Google Scholar
  • 1 January 1976
    • journal article
    • research article
    • Vol. 26  (3) , 443-449
Abstract
Parameters in radioiodine metabolism by the thyroid gland were investigated in 98 beagle pups 0-110 days of age and in 6 adults. Significant age-related differences in thyroidal 131I uptake, uptake/g of thyroid, and retention and subsequent radiation dose were observed. Significant differences were also found in uptake/g, retention, and dose between litters of the same age. Seventy day old pups had the highest mean uptake (.apprx. 25% of the administered dose) and fastest release rate (effective half-life .apprx. 3.6 day), whereas neonates less than 12 h of age showed the highest peak concentration (157% of administered dose/g thyroid). The calculated radiation doses to the thyroid were highest in newborn pups, averaging over 100 rad/MC of 131I administered, or about 10 times the dose/.mu.Ci for adults.