Prognostic Value of N-Terminal Pro–Brain Natriuretic Peptide in Patients With Chronic Stable Angina
- 4 October 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 112 (14) , 2102-2107
- https://doi.org/10.1161/circulationaha.105.550715
Abstract
Background— Patients with chronic stable angina are poorly characterized in terms of biomarkers that help in the assessment of prognosis. We investigated whether plasma levels of N-terminal pro–brain natriuretic peptide (NT-proBNP) may be used as a prognostic marker in patients with chronic stable angina treated with coronary stenting. Methods and Results— Plasma levels of NT-proBNP were measured in 1059 patients with chronic stable angina and coronary angiographic confirmation of significant coronary artery disease. The primary end point of the study was mortality. After a median of 3.6 years (interquartile range, 3.3 to 4.5 years), there were 106 deaths. Kaplan-Meier estimates of 5-year mortality were 4.7% in the first quartile, 7.8% in the second quartile, 11.4% in the third quartile, and 32.7% in the fourth quartile of NT-proBNP ( P Conclusions— Circulating levels of NT-proBNP are a strong prognostic biomarker for patients with chronic stable angina.Keywords
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