Randomized, double blind comparison of brand and generic antibiotic suspensions: I. A study of taste in adults
- 1 January 1996
- journal article
- clinical trial
- Published by Wolters Kluwer Health in The Pediatric Infectious Disease Journal
- Vol. 15 (1) , 14-17
- https://doi.org/10.1097/00006454-199601000-00003
Abstract
A belief that brand oral liquid medications taste better than their generic counterparts may influence prescribing habits among pediatricians. We undertook a prospective, randomized, double blinded, comparative evaluation of the taste of brand and generic erythromycin ethylsuccinate, cephalexin monohydrate, erythromycin ethylsuccinate/sulfisoxazole, penicillin V potassium and trimethoprim-sulfamethoxazole in 42 adult volunteers. Subjects tasted one class of brand and generic antibiotics and rated them according to smell, texture, taste and aftertaste. At least one generic preparation of cephalexin, erythromycin ethylsuccinate/sulfisoxazole and penicillin V potassium was rated equal in taste to the respective brand name products. However, brand erythromycin estolate and trimethoprim-sulfamethoxazole name brand suspensions rated significantly higher than the other products tested. Based on our results brand name oral antibiotic formulations do not necessarily taste better than their generic counterparts.Keywords
This publication has 4 references indexed in Scilit:
- Randomized, double blind comparison of brand and generic antibiotic suspensions: II. A study of taste and compliance in childrenThe Pediatric Infectious Disease Journal, 1996
- Variation in acceptance of common oral antibiotic suspensionsThe Pediatric Infectious Disease Journal, 1994
- Antimicrobial drug suspensionsThe Pediatric Infectious Disease Journal, 1994
- Antimicrobial drug suspensionsThe Pediatric Infectious Disease Journal, 1991