B cell‐deficient μMT mice as an experimental model for Mycoplasma infections in X‐linked agammaglobulinemia
- 1 August 1997
- journal article
- Published by Wiley in European Journal of Immunology
- Vol. 27 (8) , 2118-2121
- https://doi.org/10.1002/eji.1830270841
Abstract
B cell‐deficient μMT mice were investigated as an experimental model for human X‐linked agammaglobulinemia (XLA). Mice were intranasally infected with Mycoplasma pulmonis and in 16 out of 17 μMT mice, dissemination of the bacteria from the airways was observed. More than 50% of these mice developed arthritis and/or changes in periarticular tissues. Mycoplasmal infection in μMT mice thus resembles the disease seen in XLA patients implying the usefulness of the model.Keywords
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