Biological indicators for the identification of ionizing radiation exposure in humans
- 1 July 2001
- journal article
- review article
- Published by Taylor & Francis in Expert Review of Molecular Diagnostics
- Vol. 1 (2) , 211-219
- https://doi.org/10.1586/14737159.1.2.211
Abstract
While the effects of acute high-dose irradiation are well-documented, less is known about the effects of low level chronic radiation exposure. Physical dosimetry cannot always be relied upon, so dose estimates and determination of past radiation exposure must often be based upon biological indicators. Some of the established methods used in the assessment of nuclear accidents are reviewed here, including cytogenetic analyses, mutation-based assays and electron spin resonance. As interest in research on low-level radiation exposures expands, there is an increasing need for new biomarkers that can identify exposed individuals in human populations. Developments in high-throughput gene expression profiling may enable future development of a rapid and noninvasive testing method for application to potentially exposed populations.Keywords
This publication has 25 references indexed in Scilit:
- Molecular classification of cutaneous malignant melanoma by gene expression profilingNature, 2000
- Distinct types of diffuse large B-cell lymphoma identified by gene expression profilingNature, 2000
- Induction of Stress Genes by Low Doses of Gamma RaysRadiation Research, 1999
- Collective Biodosimetry as a Dosimetric “Gold Standard”Health Physics, 1997
- In vivo mutation at the human HPRT locusTrends in Genetics, 1993
- MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth ControlAnnual Review of Genetics, 1992
- Chromosomal Aberrations in Human Lymphocytes Inducedin Vitroby Very Low Doses of X-raysInternational Journal of Radiation Biology, 1992
- Increased somatic cell mutant frequency in atomic bomb survivorsMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1988
- In vivo mutant frequency rises among breast cancer patients after exposure to high doses of γ-radiationMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1985
- Dental enamel as an in vivo radiation dosimeterMedical Physics, 1985