Prostaglandin synthetase inhibitors in feverfew
- 1 October 1988
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 40 (10) , 743-745
- https://doi.org/10.1111/j.2042-7158.1988.tb07010.x
Abstract
The IC50 values for the in-vitro inhibition of the prostaglandin synthetase (bovine seminal vesicle mitochondrial fraction) mediated PGE2 production from arachidonic acid by parthenolide, michefuscalide and chrysanthenyl acetate were 11.0 ± 0.44, 121 ± 0.51 and 14.2 ± 0.58 μM (mean ± 95% confidence limits), respectively.This publication has 21 references indexed in Scilit:
- Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groupsJournal of Pharmacy and Pharmacology, 1987
- The effect of an aqueous extract of Tanacetum parthenium L. on arachidonic acid metabolism by rat peritoneal leucocytesJournal of Pharmacy and Pharmacology, 1986
- Sesquiterpene lactones and other constituents from Tanacetum partheniumPhytochemistry, 1982
- Sesquiterpene lactones from Michelia fuscataPhytochemistry, 1982
- THE ACTIVE PRINCIPLE IN FEVERFEWThe Lancet, 1981
- Antimicrobial properties and possible rôle in host-pathogen interactions of parthenolide, a sesquiterpene lactone isolated from glands of Chrysanthemum partheniumPhysiological Plant Pathology, 1979
- Constituents of the Essential Oil of Chrysanthemum japonense. Nojigiku Alcohol and Its AcetateBulletin of the Chemical Society of Japan, 1978
- Anticancer sesquiterpene lactones of Michelia compressa (magnoliaceae)Phytochemistry, 1978
- The Isolation of trans-Chrysanthenyl Acetate and Chrysanthenone from the Essential Oil of Chrysanthemum shiwogikuBulletin of the Chemical Society of Japan, 1973
- Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugsBiochemical and Biophysical Research Communications, 1972