Levels of anti-A and anti-B in commercial immune globulins

Abstract
Samples from 168 lots of immune serum globulin, tetanus immune globulin, and RhD (D) immune globulin produced by seven American manufacturers during the period 1973–1977 were analyzed for anti-A and anti-B content by saline and antiglobulin titration. There was appreciable variation among manufacturers, but between 1973 and 1975 all products showed a significant decrease in alloantibody titer. This trend did not continue during the interval 1975–1977; the titers of most manufacturers' products remained near the 1975 level. The anti-A titer of a given product was approximately one dilution higher than the anti-B; both titers were usually increased by anti-human serum, though this occurred more often in the case of anti-B.

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