An analysis of the records of 916 patients who received radiotherapy for invasive squamous cell carcinoma of the intact uterine cervix from January 1964 through December 1969 revealed that 94% of the central and regional failures will occur within 3 years of treatment. Survival rates were as follows: Stage I, 91 %; Stage IIA, 82%; Stage llB, 65%; Stage lllA, 54%; and Stage IllBs, 40%. The incidences of central and regional failures in Stages I through III are: Stages I and llA: central 2% and regional 4.5%; Stage llB: central 5% and regional 13%; Stage III: central 14% and regional 19%. In Stages llB, IIIA, and lllB, the main cause of failures, either centrally or in the parametria, is the presence of massive disease.