A new ytterbium chelate as contrast agent in chemical shift imaging and temperature sensitive probe for MR spectroscopy

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Abstract
A paramagnetic Yb(lll) complex that is the prototype of a novel class of probes for MRI and MRS has been developed. The complex displays highly shifted 1H resonances that are characterized by short relaxation times and, as such, may prove to be a valuable alternative in applications that currently require fluorine-containing probes. Selective excitation of the para-magnetically shifted resonances allows the spatial distribution of the complex to be mapped. This communication reports the images that were obtained by selectively exciting the most intense methyl group (−14.2 ppm at 27°C) for complex concentrations ranging from 0.003−0.1 M. Spectroscopically, the complex may be used as a temperature probe since the proton chemical shifts exhibit a strong temperature dependence. In human serum the chemical shift difference of a selected pair of proton resonances was observed to follow a gradient of −0.42 ± 0.01 ppm/°C. Furthermore, since the chemical shift of the methyl resonance displays a temperature coefficient of −0.04 ± 0.01 ppm/°C, it should be possible to use the image phase for thermal mapping.