Metabolites of the higher fungi. Part 18. 3-Butyl-4-methylfuran-2(5H)-one and 3-butyl-4-methylenefuran -2(5H)-one. New γ-butyrolactones from the fungus Hypoxylon serpens(Persoon ex Fries) Kickx
- 1 January 1979
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 3,p. 803-806
- https://doi.org/10.1039/p19790000803
Abstract
Culture solutions of the fungus Hypoxylon serpens contain a mixture of two isomeric γ-butyrolactones. These have been identified as 3-butyl-4-methylfuran-2(5H)-one (1a) and 3-butyl-4-methylenefuran-2(5H)-one (2). The synthesis of (1a) and the isomeric 4-butyl-3-methylfuran-2(5H)-one (1b) is described. At room temperature lactone (2) isomerises slowly to yield lactone (1a). This is the first report of the occurrence of a 4-exo-methylene γ-lactone as a natural product.This publication has 0 references indexed in Scilit: