BIOEQUIVALENCY OF RANITIDINE TABLETS
- 1 April 1989
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 14 (2) , 111-117
- https://doi.org/10.1111/j.1365-2710.1989.tb00229.x
Abstract
The bioavailability of two brands of ranitidine tablets was studied in 10 healthy volunteers. Formulation factors were compared by performing disintegration, dissolution and content uniformity tests. Plasma concentrations of ranitidine, were measured using a sensitive and precise high pressure liquid chromatographic (HPLC)procedure. Pharmacokinetic parameters were determined for both formulations and included: Cmax, AUCt, AUC.infin., tmax, t1/2 and the terminal rate of elimination (.kappa.). Statistical analysis revealed that differences between the brands were not significant. The two formulations can be considered to be bioequivalent.This publication has 9 references indexed in Scilit:
- HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC ANALYSIS OF RANITIDINE IN PLASMA AND URINEJournal of Clinical Pharmacy & Therapeutics, 1988
- The effect of age on ranitidine pharmacokineticsClinical Pharmacology & Therapeutics, 1986
- Pharmacokinetics and Bioavailability of Ranitidine in HumansJournal of Pharmaceutical Sciences, 1984
- Ranitidine disposition and systemic availability in hepatic cirrhosisClinical Pharmacology & Therapeutics, 1984
- RanitidinePublished by American Medical Association (AMA) ,1983
- Ranitidine bioavailability and kinetics in normal male subjectsClinical Pharmacology & Therapeutics, 1983
- RanitidineDrugs, 1982