Further Studies on Toxicity of Thioacetamide in Rats

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Abstract
Scarring and nodular hyperplasia of the liver were produced in rats maintained on an otherwise adequate diet containing 0.032% thioacetamide (TA). Histological changes in the liver were observed within 30 days which became progressively worse after 60 and 120 days. No spontaneous regression in the amt. of liver damage was observed in rats on 0.032% TA for 120 days and later on the basic diet for 120 days. Admn. of lipotropic factors (choline, DL-methionine, and casein) in conjunction with 0.032% TA significantly decreased liver weight. Fibrosis and various degrees of parenchymal lesions were observed in all rats on 0.032% TA with and without the lipotropic factors. It cannot be said that any of the lipotropic factors studied were effective in preventing liver damage, although there appears to have been a quantitative alteration in the character of the lesions.
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