Evidence of IgG autoantibodies against human proinsulin in patients with IDDM before insulin treatment
- 1 January 1988
- journal article
- research article
- Published by American Diabetes Association in Diabetes
- Vol. 37 (1) , 130-132
- https://doi.org/10.2337/diabetes.37.1.130
Abstract
IgG proinsulin autoantibodies (IgG-PAAs) have been found in a fraction of sera from patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM) before onset of insulin treatment. Only sera lacking insulin antibodies have been analyzed, to avoid interference. Competitive inhibition studies provide specificity for human proinsulin but not for insulin. IgG-PAAs largely cross-react with human C-peptide. Precursors of insulin thus are involved in the immune process of IDDM.This publication has 0 references indexed in Scilit: