Cerebral edema, mass effects, and regional blood volume in man

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Abstract
A quantitative analysis of computerized tomography (CT) scans was done to measure tumor size, cerebral edema and regional blood volume in man. Mass lesions without edema caused a local reduction in blood volume. Cerebral edema also reduced blood volume in proportion to its severity. Consideration of the electrolyte changes and water shifts in white matter edema suggested that the decrease in adsorption coefficient seen in CT scans was due to the increase in water content. In cerebral edema separation of blood vessels as well as increased interstitial pressure decrease blood volume, and the regional differences in turn reflect pressure gradients within the brain.