Oncogenic breakdowns in endocytic adaptor proteins
- 24 March 2005
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 579 (15) , 3231-3238
- https://doi.org/10.1016/j.febslet.2005.03.029
Abstract
Endocytosis is a versatile tool to regulate the intensity, localization, half‐life and function of signaling complexes (signalosomes) that form in cells upon binding of growth factors, cytokines and morphogens to their cognate receptors. Endocytic adaptors are non‐catalytic proteins that assemble effectors and structural components of the endocytic machinery around the trafficking cargo and serve as scaffolds for signalosomes, which in turn modify their location and activity by various post‐translational modifications. We discuss how breakdowns in the function of endocytic adaptors might facilitate impairment of tissue homeostasis and consequent tumor development.Keywords
This publication has 66 references indexed in Scilit:
- Compartmentalization of growth factor receptor signallingCurrent Opinion in Cell Biology, 2005
- Cargo- and compartment-selective endocytic scaffold proteinsBiochemical Journal, 2004
- Not just a sink: endosomes in control of signal transductionPublished by Elsevier ,2004
- Clathrin-dependent endocytosisBiochemical Journal, 2004
- Negative receptor signallingCurrent Opinion in Cell Biology, 2003
- Signal transduction and endocytosis: close encounters of many kindsNature Reviews Molecular Cell Biology, 2002
- When cell biology meets development: endocytic regulation of signaling pathwaysGenes & Development, 2002
- The endocytic pathway: a mosaic of domainsNature Reviews Molecular Cell Biology, 2001
- Endocytosis and SignalingCell, 2001
- Cell Signaling by Receptor Tyrosine KinasesPublished by Elsevier ,2000