Nondepressant .beta.-adrenergic blocking agents. 1. Substituted 3-amino-1-(5,6,7,8-tetrahydro-1-naphthoxy)-2-propanols
- 31 August 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 21 (9) , 913-922
- https://doi.org/10.1021/jm00207a014
Abstract
A series of 3-amino-1-(5,6,7,8-tetrahydronaphthoxy)-2-propanols was synthesized and investigated for .beta.-adrenergic blocking activity and direct myocardial depressant action. The cis- and trans-diols retained the .beta.-blocking potency and propranolol, but lacked its myocardial depressant action. Compound 15 (nadolol) is currently undergoing extensive clinical [human] evaluation as a potential antianginal, antiarrhythmic and antihypertensive agent.This publication has 0 references indexed in Scilit: