Renal Excretion of some Aryl Sulphate Esters in the Rat

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Abstract
The renal clearance of inulin, phenyl [35S]sulphate, naphthyl 2-[35S]-sulphate and 2-hydroxy-5-nitrophenyl [35S]sulphate was measured at various plasma concentrations in the rat. A considerable proportion of each ester was bound to plasma proteins in vivo and the ratio of 35S-labelled sulphate ester/inulin clearance demonstrated that all three esters are secreted by the renal cells. The contribution of the renal secretory process to the overall urinary excretion ranged between 22–59% (phenyl [35S]sulphate), 58–87% (naphthyl 2−[35S]sulphate) and 60–72% (2-hydroxy-5-nitrophenyl [35S]sulphate). These findings are discussed in relation to the detoxication of phenols by sulphate conjugation.