VARIATIONS IN THE BLOOD PRESSURE RESPONSE TO REPEATED ADMINISTRATION OF TETRAETHYL AMMONIUM CHLORIDE 1

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Abstract
Serial intraven. injns. of 400 mg. of tetraethyl ammonium chloride in 6 hypertensive patients following 30 min. of rest in the horizontal position revealed in all cases considerable daily fluctuation in both the magnitude of depressor response and the blood pressure floor. There was no evidence of the development of increasing tolerance to the depressor effect of the drug on repeated admn. For this reason, the data suggest that fluctuating humoral and neuro-genic mechanisms interact as factors in clinical hypertension.