Spinal fluid iodide transport in the dog

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Abstract
A technique has been developed for study of the transfer of radioiodide after injection into the ventricular spinal fluid in the anesthetized dog. I131 moves rapidly from spinal fluid to blood after intraventricular injection of a trace dose. Disappearance of I131 as measured over the head after intraventricular injection of a trace dose follows a curve suggesting the presence of multiple processes. The effects of pretreatment with intraperitoneal perchlorate or unlabeled sodium iodide have been studied. Perchlorate increases transport from blood to spinal fluid and decreases it in the opposite direction. Unlabeled iodide slows transport from spinal fluid to blood only above certain dose levels. The "barrier" to movement of iodide from blood to spinal fluid is thus probably due to transport of iodide from ventricular spinal fluid to blood, rather than to a semipermeable membrane hindering movement into spinal fluid. The properties of the transport system for I131 imply possible use in the study of spinal fluid dynamics.

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