METABOLIC DISPOSITION OF [C-14]PIVHYDRAZINE, [C-14]MEBANAZINE, AND [C-14]BENZYLHYDRAZINE IN THE RAT

  • 1 January 1979
    • journal article
    • research article
    • Vol. 7  (6) , 388-392
Abstract
The hydrazine drugs [used to treat depression and hypertension], [14C]pivhydrazine and [14C]mebanazine and the related compound [14C]benzylhydrazine were readily absorbed from the rat gut and the radioactivity was excreted mainly in urine. The major urinary metabolite of pivhydrazine and benzylhydrazine was [14C]hippuric acid, but mebanazine was excreted largely unchanged. Biliary excretion (21 and 24%, respectively) of radioactive material was observed after administration of [14C]pivhydrazine and [14C]mebanazine to bile duct-cannulated rats but only small amounts (.apprx. 3%) were excreted in bile after [14C]benzylhydrazine administration. The major biliary metabolities of pivhydrazine and mebanazine are acid-labile conjugates, possibly N-glucuronides. In vitro studies with rat liver homogenate suggest that benzylhydrazine may be an intermediate in the metabolism of pivhydrazine. The distribution of radioactivity in the rat 7 days after the administration of [14C]pivhydrazine and [14C]mebanazine is described.