Using HPV Chemical Data to Develop QSARs for Non‐HPV Chemicals: Opportunities to Promote More Efficient Use of Chemical Testing Resources

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Abstract
There are opportunities to use data developed for High Production Volume (HPV) chemicals to save chemical testing resources for non‐HPV chemicals. First, data being developed for HPV chemicals could reduce chemical testing resources for non‐HPV chemicals, if the data can be used to develop and validate Quantitative Structure Activity Relationships (QSARs) that can be used to make predictions for non‐HPV chemicals. Second, strategies need to be developed to identify chemicals for which QSARs may not make reliable predictions and appropriate tests need to be conducted so that these and related chemicals can be included in more robust QSAR predictions. This paper illustrates the chemical testing resources that could be saved by using QSAR predictions and discusses guidelines and issues that need to be addressed before using data from HPV chemicals to develop QSARs for non‐HPV chemicals.