Acromegaly

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Abstract
ACROMEGALY, well described in antiquity, was recognized as a distinct clinical syndrome by Marie in 1886.1 The pituitary source of the disorder was confirmed in 1909 by Cushing, who postulated the excessive secretion of growth-promoting hormone by a hyperfunctioning pituitary gland.2 Recent progress in the diagnosis and treatment of this fascinating clinical syndrome has been reviewed.3 4 5 6 7 Advances in neuroendocrinology have resulted in the development of novel neuropeptide medications that herald a new era of pharmacologic management of hormone-secreting tumors. This review focuses on advances in our understanding of the pathophysiology of acromegaly, diagnosis of the various forms of the disorder, . . .