Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis
- 1 January 1984
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 307 (5948) , 241-245
- https://doi.org/10.1038/307241a0
Abstract
The downstream (3'') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5'') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.Keywords
This publication has 28 references indexed in Scilit:
- Endogenous avian retroviruses contain deficient promoter and leader sequences.Proceedings of the National Academy of Sciences, 1983
- Sequence comparison in the crossover region of an oncogenic avian retrovirus recombinant and its nononcogenic parent: genetic regions that control growth rate and oncogenic potential.Molecular and Cellular Biology, 1982
- Effect of intron size on splicing efficiency in retroviral transcriptsNucleic Acids Research, 1982
- On the mechanism of retrovirus-induced avian lymphoid leukosis: deletion and integration of the proviruses.Proceedings of the National Academy of Sciences, 1981
- Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertionCell, 1981
- The primary transcription unit of the mouse β-Major globin geneCell, 1981
- Analysis of avian leukosis virus DNA and RNA in bursal tumors: Viral gene expression is not required for maintenance of the tumor stateCell, 1981
- Nucleotide sequence analysis of the Long Terminal Repeat (LTR) of avian retroviruses: Structural similarities with transposable elementsCell, 1980
- Unusual features in the nucleotide sequence of a cDNA clone derived from the common region of avian sarcoma virus messenger RNA.Proceedings of the National Academy of Sciences, 1980
- Proviruses of avian sarcoma virus are terminally redundant, co-extensive with unintegrated linear DNA and integrated at many sitesCell, 1978