Synthesis of cyclic oligonucleotides by a modified phosphotriester approach
- 1 January 1988
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 16 (10) , 4607-4620
- https://doi.org/10.1093/nar/16.10.4607
Abstract
Evidence will be presented to show that the allyl group is suitable for the protection of a 3'-terminal phosphodiester function. The latter will be demonstrated by the synthesis, via a phosphotriester approach, of two cyclic tetraribonucleotides [r(AAAA) and r(UAMe2UAMe2)], two cyclic hexadeoxyribonucleotides [d(CGCGCG) and d(TAAAAA)] and a cyclic octadeoxyribonucleotide [d(CGTGCGTG)].Keywords
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