In vitro Inhibitory Activity of Soluble ICAM-1 for the Numbered Serotypes of Human Rhinovirus
- 1 December 1993
- journal article
- Published by SAGE Publications in Antiviral Chemistry and Chemotherapy
- Vol. 4 (6) , 323-327
- https://doi.org/10.1177/095632029300400603
Abstract
We studied the antirhinovirus activity of soluble intercellular adhesion molecule-1 (sICAM-1) against all 100 numbered human rhinovirus (HRV) serotypes in human embryonic lung fibroblast (HEL) cells. sICAM-1 inhibited replication of 88 of 90 HRVs belonging to the major receptor group with 50% effective concentrations (EC50) ranging from 0.1 to 41.1 μg ml−1 (~0.002 to 0.8 μM). No inhibition at 100 μg ml−1 (~2 μM) was observed for HRV belonging to the minor receptor group, type 87, and two serotypes of the major receptor group (types 23 and 25). Yield reduction assays done with five HRV serotypes in human adenoid expiants found that sICAM-1 had concentration-dependent inhibitory effects that correlated closely with the activity observed in HEL cells ( r2 = 0.99, P < 0.001).Keywords
This publication has 19 references indexed in Scilit:
- In vitro studies of the antirhinovirus activity of soluble intercellular adhesion molecule-1Antimicrobial Agents and Chemotherapy, 1992
- The major and minor group receptor families contain all but one human rhinovirus serotypeVirology, 1991
- Respiratory Virus Infection of Monolayer Cultures of Human Nasal Epithelial CellsAmerican Review of Respiratory Disease, 1990
- The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirusCell, 1990
- A soluble form of intercellular adhesion molecule-1 inhibits rhinovirus infectionNature, 1990
- Modelling of the human intercellular adhesion molecule‐1, the human rhinovirus major group receptorProteins-Structure Function and Bioinformatics, 1990
- Protective effect of rhinovirus receptor blocking antibody in human fibroblast cellsAntiviral Research, 1989
- The major human rhinovirus receptor is ICAM-1Published by Elsevier ,1989
- A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinovirusesCell, 1989
- In vitro activity of R 61837, a new antirhinovirus compoundArchiv für die gesamte Virusforschung, 1988