Inability to induce keratinization in basal cell tumors. Wounding and application of resin podophyllum
- 1 June 1967
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Dermatology
- Vol. 95 (6) , 576-582
- https://doi.org/10.1001/archderm.95.6.576
Abstract
Basal cell tumors were superficially wounded or exposed to 24-hour occlusive applications of 0. 5 percent resin podophyllum in alcoholic solution. These stimuli did not induce the tumor cells to participate in the healing process nor to show any detectable sign of keratinization. These observations support the hypothesis that basal cell tumors are derived from cutaneous epithelial cells which have lost the capacity of keratinization.This publication has 4 references indexed in Scilit:
- Morphologic and Physiologic Effects of Chemotherapeutic Agents in Psoriasis11From the Dermatology Service, General Medicine Branch, National Cancer Institute, (National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare) Bethesda, Maryland.Journal of Investigative Dermatology, 1959
- The Biological Effects and the Chemical Composition of Podophyllin. A ReviewJNCI Journal of the National Cancer Institute, 1954
- Effects of Podophyllin on Mouse Skin. II. Consideration of Some Functional Aspects23JNCI Journal of the National Cancer Institute, 1949
- Effects of Podophyllin on Mouse Skin. I. Histologic Sequence after a Single Dose23JNCI Journal of the National Cancer Institute, 1948