N-Alkylation of Secondary Amine Tricyclic Antidepressants as a General Method for Their Quantitation by GC-MS-SIM Technique. Preparation of N-Ethyl Derivatives of Desimipramine, Nortriptyline, Protiptyline and Desmethyldoxepin

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Abstract
A simple method for the preparation of N-ethyl derivatives of secondary amino tricyclic antidepressants is described, using dimethylformamide diethyl acetal as the alkylating reagent. The GC data and electron impact and chemical ionization mass spectra of N-ethyl derivatives are presented. The use of these derivatives in the quantitation of plasma levels of these drugs in clinical studies is discussed.

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