The Effect of the Use of Different Tissue Extracts on One-Stage Prothrombin Times

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Abstract
The effect of the use of a variety of thromboplastin reagents on the results of the one-stage prothrombin determinations was studied. These consisted of 3 human brain, 5 animal extracts and 3 reagents which incorporate adsorbed plasma[long dash]Withington, 2, 7, 10 and thrombotest. Nine of 10 tissue extracts gave results of the same order. The 3 more complex adsorbed plasma reagents were alike in their results but their therapeutic range appeared to be substantially lower in percentage activity. The therapeutic range with every type of thromboplastin must be established individually, either on the basis of clinical experience or parallel observation with a standard reagent. Standardization of thromboplastin reagent is necessary, not only for clinical trials but also that there may be a common basis for dosage of anticoagulant drugs.

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