METHOTREXATE MEGADOSE FOLLOWED BY FOLATE RESCUE II CLEARANCE PATTERNS IN PATIENTS RECEIVING SEQUENTIAL MEGADOSE INFUSIONS
- 1 July 1962
- journal article
- Published by AMPCo in The Medical Journal of Australia
- Vol. 1 (22) , 826-828
- https://doi.org/10.5694/j.1326-5377.1976.tb141090.x
Abstract
In some patients receiving megadose infusions of methotrexate (MTX), the rate of drug clearance decreases with each subsequent infusion. This can be modified by administration of fluids as outlined in the Recommended Protocol. Monitoring of each treatment is needed to assess requirements of fluids since these cannot be adequately predicted from data of previous infusions.Keywords
This publication has 1 reference indexed in Scilit:
- METHOTREXATE MEGADOSAGE FOLLOWED BY FOLATE RESCUE I. A STUDY IN CLEARANCE PATTERNSThe Medical Journal of Australia, 1962