On the causal association between exposure to leather dust and nasal cancer: further evidence from a case-control study.
Open Access
- 31 January 1986
- journal article
- research article
- Published by BMJ in Occupational and Environmental Medicine
- Vol. 43 (2) , 91-95
- https://doi.org/10.1136/oem.43.2.91
Abstract
A case-control study was performed on the incident cases of nasal cavity tumours which occurred between 1968 and 1982 among the residents of Vigevano (Lombardy region, northern Italy). This area is characterised by a high prevalence of shoemakers (especially in leather); the activity has predominated in Vigevano since the beginning of this century. Twenty one cases were identified (16 men and five women); 20 were histologically confirmed as nasal epithelial tumours; 17 had already died at the time of interview and the occupational history was obtained from the next of kin. Two controls per case were selected from the general population and matched by vital status, age, sex, and residence. The overall odds ratio for the subjects exposed to leather dust was 47.1 for men and 3.5 for women. The odds ratio was higher for adenocarcinoma and among the workers exposed to the worst working conditions. A significant trend for the level of exposure to leather dust was found. Nevertheless, even the jobs characterised by a relatively low exposure were found to have a significantly higher risk (OR = 7.5). Smoking habits and exposure to solvents are unlikely to confound the relation between exposure to leather and nasal tumours.This publication has 11 references indexed in Scilit:
- Mortality of tanners.Occupational and Environmental Medicine, 1985
- Occupational formaldehyde exposure and increased nasal cancer risk in manInternational Journal of Cancer, 1984
- Nasal cancer in the Northamptonshire boot and shoe industry: is it declining?British Journal of Cancer, 1982
- Epidemiological study of nasal and nasopharyngeal cancer and their relation to phenoxy acid or chlorophenol exposureAmerican Journal of Industrial Medicine, 1982
- Adenocarcinoma of the nose and paranasal sinuses in shoemakers and woodworkers in the province of Florence, Italy (1963-77).Occupational and Environmental Medicine, 1980
- LEUKEMIA ASSOCIATED WITH BENZENE EXPOSUREAnnals of the New York Academy of Sciences, 1976
- ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIESAmerican Journal of Epidemiology, 1976
- Nasal Cancer in the Northamptonshire Boot and Shoe IndustryBMJ, 1970
- Statistical Aspects of the Analysis of Data From Retrospective Studies of DiseaseJNCI Journal of the National Cancer Institute, 1959