IMMUNOGOLD LABELING OF CEREBROVASCULAR AND NEURITIC PLAQUE AMYLOID FIBRILS IN ALZHEIMERS-DISEASE WITH AN ANTI-BETA PROTEIN MONOCLONAL-ANTIBODY
- 1 October 1987
- journal article
- research article
- Vol. 57 (4) , 446-449
Abstract
A monoclonal antibody raised to a synthetic peptide consisting of residues 8 to 17 of the amyloid .beta. protein of Alzheimer''s disease was employed for immunogold electron microscopic studies on amyloid fibrils of cerebrovascular walls and neuritic plaques in this disease. Electron microscopy revealed a specific gold labeling of the amyloid fibrils in these structures. This provides ultrastructural evidence that .beta. protein is intimately associated with the amyloid fibril. With previous chemical evidence, this observation supports the contention that it is an intrinsic component of the fibril.This publication has 7 references indexed in Scilit:
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