Control of B-cell responses by Toll-like receptors
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- 17 November 2005
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 438 (7066) , 364-368
- https://doi.org/10.1038/nature04267
Abstract
Toll-like receptors (TLRs) detect microbial infection and have an essential role in the induction of immune responses1,2,3. TLRs can directly induce innate host defence responses, but the mechanisms of TLR-mediated control of adaptive immunity are not fully understood. Although TLR-induced dendritic cell maturation is required for activation of T-helper (TH) cells4, the role of TLRs in B-cell activation and antibody production in vivo is not yet known. Here we show that activation and differentiation of TH cells is not sufficient for the induction of T-dependent B-cell responses. We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells.Keywords
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