Oligoribonucleotide Synthesis. V. Preparation of 2′-O-Tetrahydropyranyl Derivatives of Guanosine and Their Insertion into a General Stepwise Synthesis
- 1 April 1973
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Chemistry
- Vol. 51 (7) , 1068-1074
- https://doi.org/10.1139/v73-158
Abstract
The syntheses of N2-benzoyl-2′-O-tetrahydropyranylguanosine (5) and its corresponding 5′-O-tri-phenylmethoxyacetyl derivative (6) are described. Compounds 5 and 6 are the protected derivatives of guanosine required for insertion into a phosphotriester synthesis for oligoribonucleotides. Syntheses of GpC and GpG were carried out to illustrate incorporation of 5 and 6 into a sequence.Keywords
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