Local Anaesthetic Activity in Diethylaminoacetyl Derivatives of Substituted Benzylamines
- 1 December 1962
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 14 (Supplement) , 48T-58T
- https://doi.org/10.1111/j.2042-7158.1962.tb10529.x
Abstract
Six diethylaminoacetyl derivatives of general formula (III) are more potent than lignocaine as local anaesthetics. All cause erythema or necrosis of guinea-pig skin on intradermal injection except III, R = NH2, R' = H, and R = O(CH2)2Ph. This compound is several times more potent than lignocaine and in equipotent concentrations did not cause any tissue damage to skin on intradermal injection.Keywords
This publication has 2 references indexed in Scilit:
- 34. The chemotherapy of schistosomiasis. Part V. Cholesteryl and choloyl derivatives of 4-amino-2-methoxyphenyl ethersJournal of the Chemical Society, 1962
- Studies on Local Anesthetics XXII**Received April 16, 1959, from the Department of Pharmaceutical Chemistry, Masaryk University, Brno, Czechoslovakia.Journal of the American Pharmaceutical Association (Scientific ed.), 1960