One of the retinoic acid‐inducible cDNA clones in mouse embryonal carcinoma F9 cells encodes a novel isoenzyme of fructose 1,6‐bisphosphatase

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Abstract
Rae‐30, one of the retinoic acid (RA)‐inducible cDNA clones in mouse embryonal carcinoma F9 cells, was sequenced and the deduced RAE‐30 protein showed about a 70% homology to mammalian fructose 1,6‐bisphosphatase (EC 3.1.3.11) (FBPase), in comparison to over 85% homology observed among the previously documented rat liver, pig kidney and human leukemic HL‐60 cell FBPases. The Rae‐30 mRNAs were not detected in various tissues of adult mice, including the liver and kidney, but were detected in a placenta and predominantly in the intestine of adult mice. These findings indicate that the Rae‐30 cDNA encodes a novel isoenzyme of FBPase, which is likely to be involved in early differentiation in mammalian cells.