Metabolic Response to Isologous Transplantation of Small Numbers of Isolated Islets of Langerhans in the Rat
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 9 (6) , 411-418
- https://doi.org/10.1159/000127962
Abstract
Pancreatic islets from adult donors were transplanted intraportally into 32 inbred, adult AGUS rats with streptozotocin diabetes. The islets were isolated with collagenase and counted individually. A relationship between the number of islets transplanted and the metabolic response could be demonstrated. Transplantation of less than 200 islets did not change the diabetic state. Rats receiving 200-220 improved, while recipients of 240-800 islets all exhibited normal values of blood glucose, plasma insulin, urine volume and urine glucose. The glucose tolerance remained abnormal in all animals.Keywords
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