The proliferative behavior of the human adult mammary epithelium.

  • 1 May 1979
    • journal article
    • Vol. 23  (3) , 252-7
Abstract
Normal, human, resting, breast tissue was cultured in the defined culture medium 199 with and without insulin. DNA synthesis was assessed by use of autoradiography. A labeling index (LI) showed a different sensitivity in terms of DNA synthesis in the three basic segments of the mammary tree: intralobular ductules, terminal ducts and large ducts. The LI increased significantly after six hours in the terminal ducts, both in the basic unenriched 199 medium and in the presence of 1 microgram/ml insulin. Cumulative LIs were representative of the interlobular ducts, the most active part of breast epithelium.

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