Variable Expression Patterns of Mycobacterium tuberculosis PE_PGRS Genes: Evidence that PE_PGRS16 and PE_PGRS26 Are Inversely Regulated In Vivo
- 15 May 2006
- journal article
- Published by American Society for Microbiology in Journal of Bacteriology
- Vol. 188 (10) , 3721-5
- https://doi.org/10.1128/jb.188.10.3721-3725.2006
Abstract
Evaluation of expression of 16 PE_PGRS genes present in Mycobacterium tuberculosis under various growth conditions demonstrated constitutive expression of 7 genes, variable expression of 7 genes, and no expression of 2 genes. An inverse expression profile for genes PE_PGRS16 and PE_PGRS26 was observed to occur in macrophages and in mice infected with M. tuberculosis . Variable expression of PE_PGRS proteins could have implications for their role in the immunopathogenesis of tuberculosis.Keywords
This publication has 23 references indexed in Scilit:
- Expression of the PE_PGRS 33 protein in Mycobacterium smegmatis triggers necrosis in macrophages and enhanced mycobacterial survivalMicrobes and Infection, 2006
- Identification of Cyclic AMP-Regulated Genes in Mycobacterium tuberculosis Complex Bacteria under Low-Oxygen ConditionsJournal of Bacteriology, 2005
- Mechanisms of Azole Resistance in Clinical Isolates of Candida glabrata Collected during a Hospital Survey of Antifungal ResistanceAntimicrobial Agents and Chemotherapy, 2005
- Transcription Regulation by the Mycobacterium tuberculosis Alternative Sigma Factor SigD and Its Role in VirulenceJournal of Bacteriology, 2004
- Whole-Genome Comparison ofMycobacterium tuberculosisClinical and Laboratory StrainsJournal of Bacteriology, 2002
- ideR , an Essential Gene in Mycobacterium tuberculosis : Role of IdeR in Iron-Dependent Gene Expression, Iron Metabolism, and Oxidative Stress ResponseInfection and Immunity, 2002
- Comparative Immune Response to PE and PE_PGRS Antigens of Mycobacterium tuberculosisInfection and Immunity, 2001
- A Novel Method to Compensate for Different Amplification Efficiencies between Patient DNA Samples in Quantitative Real-Time PCRThe Journal of Molecular Diagnostics, 2001
- Granuloma-Specific Expression of Mycobacterium Virulence Proteins from the Glycine-Rich PE-PGRS FamilyScience, 2000
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998