EFFECT OF PSYCHOTHERAPEUTIC DRUGS ON HYPEREMOTIONALITY OF RATS IN WHICH THE OLFACTORY BULB WAS REMOVED

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Abstract
Rats with lesions in the olfactory bulb [O. B.] of the forebrain become extremely hyperemotional. This behavioral change remained for more than about 200 days and was depressed by the following drugs (in decreasing order of potency): reserpine, chlorpromazine, chlorprothixene, chlordiazepoxide, benzperidol, phenobarbital and meprobamate. Chlordiazepoxide depressed hyperemotionality of the O. B. -rats more pronouncedly than general activity of normal rats. Antidepressant agents had only a slight effect. Dose levels of chlordiazepoxide, chlorpromazine and reserpine which almost completely inhibited hyperemotionality and general activity were required to only moderately depress fighting behavior.