Arthritogenicity of Wax D from Various Mycobacteria Related to Oil Vehicle Composition and to the Combination with Poly I:C, Cord Factor and Acetylated Wax D
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 53 (4) , 357-365
- https://doi.org/10.1159/000231772
Abstract
Most of wax D (peptidoglycolipid) used here appeared to be ineffective for production of arthritis when given in a water-in-oil emulsion, while the same wax D in squalane was very effective for production of arthritis. Arlacel A as an emulsifier appeared to suppress the arthritogenicity of wax D in squalane, probably through some interaction with the arthritogenic portion of wax D. Poly 1:C seemed to remarkably enhance the arthritogenicity of wax D, even in water-in-oil emulsion. Acetylated wax D and cord factor (trehalose-dimycolate) were much less effective than poly 1:C. Delayed skin hypersensitivity to PPD, peptidoglycan and poly 1:C was also markedly affected by oil composition. However, there was no correlation between these delayed hypersensitivities and development of arthritis.Keywords
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