Peptide‐urea interaction

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Abstract
The excess enthalpies of the ternary aqueous solutions containing urea and the glycyl‐glycine, glycyl‐L‐alanine, L‐alanyl‐L‐alanine and sarcosyl‐sarcosine diketopiperazines respectively have been determined. A weak but favourable enthalpic contribution to the interaction between these solutes is found. The difference between “strong” and “weak” interactions in aqueous solutions of non‐electrolytes is stressed and the role of water in the weak, non‐specific interactions, is discussed. The consequence of the weakness of the urea‐peptide interactions on the binding of urea to the proteins is also briefly discussed.