Event-Related Potentials in Human Immunodeficiency Virus Infection

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Abstract
• P3event-related evoked potentials (ERP) were recorded from 47 human immunodeficiency virus (HIV)—positive subjects examined twice and 29 HIV-positive subjects examined three times at 6-month intervals. The P3latency significantly increased over time for asymptomatic subjects and subjects with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. N2latency was prolonged relative to control values in both HIV-positive groups but did not increase with time. The P3latency correlated with neuropsychologic measures of motor control and speed of mental processing. Confounding factors (active or previous substance abuse, developmental disabilities, and history of closed head injury or epilepsy) did not significantly affect ERP latencies. Endogenous ERP components are frequently abnormal in HIV-positive subjects and the P3latency progressively increases over time. Continued follow-up is required to determine the clinical utility of ERP studies in the HIV-positive population.

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