CORRELATIONS BETWEEN RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID METABOLISM DURING SPORE GERMINATION

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Abstract
Nucleic acid metabolism during the germination of spores of Bacillus subtilis differs from that found in the vegetative cell. During the initial 2 hr, of germination, ribonucleic acid (RNA) only is synthesized. By the end of this time the total cell RNA has approximately doubled. Deoxyribonucleic acid (DNA) synthesis begins at 2 hr, of germination, and the onset of optical density increase in the culture is coincident with this. Spore RNA is labile during germination. It is essentially completely turned over at the time DNA synthesis begins. There is a dramatic increase in the rate of RNA synthesis at, or shortly after, the onset of DNA synthesis. There is a similar increase in the rate of DNA synthesis at the time of the first cell division.