Formation of dna adducts and water-soluble metabolites of benzo[a]pyrene in human monocytes is genetically controlled

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Abstract
Formation of DNA adducts and of water‐soluble metabolites was studied in monocytes of 86 first‐degree relatives of 15 families. Tests were performed with blood monocytes using (G‐3H)‐benzo[a]pyrene as a model pro‐carcinogen. Variance analysis revealed significantly higher inter‐familial than intra‐familial variations. From these data we conclude that the formation of DNA adducts is genetically controlled. Therefore the enhanced formation of benzo[a]pyrene DNA adducts in lung cancer patients found in earlier studies may reflect a genetic predisposition for lung cancer in some patients.