MEASUREMENTS OF INTESTINAL PERMEABILITY USING LOW-MOLECULAR WEIGHT POLYETHYLENE GLYCOLS (PEG-400) .2. APPLICATION TO NORMAL AND ABNORMAL PERMEABILITY STATES IN MAN AND ANIMALS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 73  (2) , 247-251
Abstract
A new approach to the measurement of intestinal permeability using low MW polyethylene glycols (PEG 400) was applied to the study of normal and abnormal permeability states in man and animals [dogs]. Successful assessments of gastric, jejunal, ileal and colonic permeability suggest that the technique has application to any area of the gastrointestinal tract. The method has shown that bile acids after mucosal permeability in the stomach and colon and that celiac sprue is associated with decreased intestinal permeability. These examples illustrate the techniques potential for studying of the function of diseased intestine in man.

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