THE DEVELOPMENT AND EVALUATION OF AN OVULATION INHIBITOR (DIANE®) CONTAINING AN ANTIANDROGEN

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Abstract
The combination of 2 mg cyproterone acetate, a pronounced antiandrogenic substance, in combination with 0.05 mg ethinyl estradiol has undergone intensive multiphasic clinical evaluation. the preparation with the trade name Diane® has proven to be not only a reliable contraceptive, but also a very potent drug for the treatment of both acne and seborrhea, and of milder cases of hirsutism. the effect of Diane® on markedly increased hair growth was not so pronounced. in addition to the presentation of the most pertinent steps of the clinical investigation of Diane®, the possible mode of actions of antiandrogens alone and in combination with an estrogen is discussed.