INFECTION STUDIES IN KITTENS, USING FELINE INFECTIOUS PERITONITIS VIRUS PROPAGATED IN CELL-CULTURE

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  • 1 January 1981
    • journal article
    • research article
    • Vol. 42  (3) , 363-367
Abstract
The propagation of feline infectious peritonitis virus (NW1-FIPV strain) in cell culture is described. Tissue culture-propagated virus was used to inoculate specific pathogen-free kittens i.p., intratracheally or orally. I.p. inoculation caused seroconversion and effusive peritonitis in 100% of the kittens. Intratracheal inoculation produced disease in 60% of the kittens and oral inoculation in only 20%. Seroconversions without production of disease occurred in 10% of the kittens inoculated by either the intratracheal or the oral route. The remainder of the kittens inoculated by the intratracheal (30%) and oral (70%) routes did not develop serum antibodies or disease.